freethefly

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  1. Man, he LOOKS stoned. Found this surfing. Thought it was funny. "...And once you're gone, you can't come back When you're out of the blue and into the black." Neil Young
  2. I predict he will own a fleet of them nationwide, including Washington DC, where which he will hold the deeds to most Federal Buildings after his lawsuit. "...And once you're gone, you can't come back When you're out of the blue and into the black." Neil Young
  3. He would most likely sue the hell out of D.C. and retire in Florida along with the millions he would make by selling the movie rights. "...And once you're gone, you can't come back When you're out of the blue and into the black." Neil Young
  4. Why is that? What would be so great about legalizing marijuana? The economic boom for one thing. Lessening the burden on the court system. Alowing otherwise responsiable and law abiding adults the freedom of choice without fear of incarceration. Allowing those in need of the medical mj to obtain without relying on a blackmarket. Legalization will also wreak havoc on the blackmarket of mj, thus making it less profitable for dealers and more for the state and city if a system to tax was imposed. Legalization will also free the police to focus on more pressing issues. It is my understanding, from what I hear from my nephew whom is a police officer, that most cops really hate having to arrest for pot and view it as a waste of time to do so when they should be looking for more serious offenders instead of filling out paperwork for a bag of grass. I think the list of why it is in the interest of this nation and the world to allow, across the board, the legalization of mj, goes on and on. Economics, medical, biofuels, food, fiber, enviromental... Just google the reasons or go to www.norml.org. "...And once you're gone, you can't come back When you're out of the blue and into the black." Neil Young
  5. There's not been a war yet that has MADE money for the U.S. U.S. weapons manufacturers make an ungodly amount of money. The people who profit from weapons, I am sure, pray for war and destruction. Without it, they are out of a job and so are the people they employe to work on the assembly lines. It is ashame that the world does not put as much effort into the labor of creating peace as it does into creating new conflict. "...And once you're gone, you can't come back When you're out of the blue and into the black." Neil Young
  6. Your header is bogus. Biofuel does not destroy the rainforest. It is the humans who cannot manage a grow operation. It is their greed to fill their pockets. There is plenty of open range to fill the need, worlwide. Their are plenty of impoverished nations that could benefit from biofuel grow operations. Blame all destruction on the greedy not the fuel. "...And once you're gone, you can't come back When you're out of the blue and into the black." Neil Young
  7. Many, many people in the US lag somewhat in awareness of HIV and it's consequence. Think about it from the point of view of dying. Sometimes that hot nookie really doesn't seem that hot anymore. There's a lot more to sex than pregnancy. t I was going to say something along the same line. As someone living with HIV I am amazed how unaware most people are about how dangerous HIV is. A large number of the U.S. population is unaware of their status and this has caused an onslaught of newly infected. What if LaFave was infected? What about all the other teachers or any adult who prey on young boys and girls? They put these children in great risk. My opinion is anyone who preys on children should be given a life sentence without parole. They are destroying the childhood of their victim, these predators should be shown no mercy. No justice was served here which is all to typical in our courts. Her lawyer stated that she was far to pretty to be put in prison and it is appearant that the idiot D.A. agreed. No doubt she will strike again. "...And once you're gone, you can't come back When you're out of the blue and into the black." Neil Young
  8. Thanks to D.B. Cooper, you cannot open doors inflight. "...And once you're gone, you can't come back When you're out of the blue and into the black." Neil Young
  9. Hey, The Boss Rocks. Bought my first Springsteen album in 1973 and I still have all of them. GREETINGS FROM ASBURY PARK...Blinded by the Light (cut loose like a deuce), It's Hard to be a Saint in the City, Does this Bus Stop at 82nd Street? If that's not enough to convince those who say he has no talent then take a listen to The Wild, The Innocent and the E Street Shuffle. 4th of July, Asbury Park (Sandy), Incident on 57th Street, Kitty's Back. Springsteen's music is pure American rock that came from the streets he grew up on. He should be honored, all politics aside, for his contribution to the arts. Someone posted that he can't sing well. Sure he probally wouldn't last one day on American Idol. But, then neither would Willie Nelson, Neil Young or a host of other balladeers. But what would the has beens who judge that show know about true talent. I grew up listening to The Boss and saw him several times in the 70's. He is an American icon and his music does reflect the American landscape. Pity that the politics of the simple minded politicians who voted down will keep him from an honor justly deserved. Regardless, he will always be honored by those who recognize his genius. "...And once you're gone, you can't come back When you're out of the blue and into the black." Neil Young
  10. Will not change a thing. I am sure someone has already stepped in to fill his slot. Possiably someone worst ( not hard to imagine someone more ruthless than that scumbag ). This shit will never end. If he is dead, good. "...And once you're gone, you can't come back When you're out of the blue and into the black." Neil Young
  11. No time to celebrate! Very busy this time of year polishing brass casings in anticipation that jollyboy will be on the business side of the crosshairs. Yup, still gunning for saint dick as I have not nor will I ever forget the major blunder of 1968 when I did not get my Super Scientist kit with all the good chemicals included.That fat ass velvet boy will wish he stayed put with his queer deer Rudolph and the elfs. Last year was a bust and sleighboy got through unscathed. It WILL be differant this year. I have been in touch with the R & D boys in a clandestine weapons lab south of Fort Wayne, Indiana. They have assured me that this year I will be mounting a team of reindeer heads and burying one very fat sleigh pilot. I know what this means to the people south of me. They are sure not to get a visit from the king of sweatshops if my shot is true and it will be. This years weapon of choice is a cold ass seeking round. In the past I used heat seeking technology to blast that deer loving bastard out of the sky to no avail. My sources have informed me that for years Santa has been on to me. All this time I believed that I have fell off of his radar. The intelligence report tells me that he has been shoving ice cubes up his ass to fool my heatseekers. He has also been stuffing them up the butts of his reindeer so as not to lose a deer to a missle. My god he has to be stopped. What kind of sick fuck shoves ice cubes up the ass of a deer? Well, time is nearing and the new cold ass seeking technology will soon allow me peace at last. Yup, when that fat bastard comes ho-ho-ho-ing across my sky... it will look more like the 4th of july than christmas. Candyboy will wish he never had shorted me on my share of the loot back in 68. SANTA YOU CHEAP, UNION BUSTING PRICK!!!! I'll mount his head along with the reindeer. I feel better already. "...And once you're gone, you can't come back When you're out of the blue and into the black." Neil Young
  12. I can only guess to whom the 3 are who think old GW is doing a good job "...And once you're gone, you can't come back When you're out of the blue and into the black." Neil Young
  13. I have been feeling a bit mean... "...And once you're gone, you can't come back When you're out of the blue and into the black." Neil Young
  14. No, but pot should be made legal. Marijuana should be as legal as tobbacco is, considering that cannabis has been proven time and time again to be worthy of a place in society and should not be catagorized with hard narcotics (many of which are legal pharmetcuticals and are highly dangerous). The problem with marijuana's image is the villifying propaganda put out by the government. As early as 1965 I have heard of the "DANGER of MARIJUANA". The same message is applied today dispite the advances in the science of the plant and it's compounds. It is amazing that the government is still halting studies to advance the medicinal value of a plant that has been so widely used for centuries. At the same time they have increased the arrest number to more than 750,000 for the year 2004. 80% of those were for simple possession. The economics of those arrest are devestasting to any and all communities. The majority of pot arrest are regular, hard working people with families who are law abiding, other than smoking marijuana. Most everyone would agree as most everyone has family members who smoke or friends who smoke. Most people know at least one person who has been arrested and knows what that person went through. The cost of prohibition has been the costliest endeavor that the federal government has ever imposed and has had zero positive affect, only negative. Prohibition created a blackmarket for the demand of marijuana and subsequintialy created a federal department (the DEA which grew from the Federal Bureau of Narcotics) to fight the offenders, which only increased the prison population and demanded more money. The good that could be done by studying, legalizing, regulating and taxing marijuana far outweigh any argument for continuing prohibition. The science has far surpass the unfounded propaganda against it's use. It is hopefully only a matter of time till the federal government realizes this. "...And once you're gone, you can't come back When you're out of the blue and into the black." Neil Young
  15. How's your arse feel after this? shropshire Jumps License In sport : 155 : C : Oct 19, 2005, 4:48 PM Post #1 of 12 (82 views) Copy Shortcut Registered: Apr 20, 2004 Posts: 1094 Controversial? Including complete posts when replying..agggh! - NEW Quote | Reply -------------------------------------------------------------------------------- Is it just me or does anyone else find the current practise of copy and pasting the ENTIRE contents of the post being replied to in a response, a pain in the arse? Often many...many .... many paragraphs If the initial post was interesting.... we all read it If it wasn't .... including it again doesn't improve it any..... Just my 2p worth. Tony _________________________________ If I'm the best result of 100Million wrigglers, Then thank fuck the others never made it ;-) flyangel2 Jumps License In sport : 3333 : D : 26 years Oct 19, 2005, 4:51 PM Post #2 of 12 (80 views) Copy Shortcut Registered: Oct 25, 2002 Posts: 9879 Re: [shropshire] Controversial? Including complete posts when replying..agggh! - NEW [In reply to] Quote | Reply -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- In Reply To -------------------------------------------------------------------------------- Is it just me or does anyone else find the current practise of copy and pasting the ENTIRE contents of the post being replied to in a response, a pain in the arse? Often many...many .... many paragraphs If the initial post was interesting.... we all read it If it wasn't .... including it again doesn't improve it any..... Just my 2p worth. -------------------------------------------------------------------------------- Bawhaha.......I know who does that BTW, it isn't necessary to copy the whole post. WOW WHAT A RIDE!! shropshire Jumps License In sport : 155 : C : Oct 19, 2005, 4:52 PM Post #3 of 12 (77 views) Copy Shortcut Registered: Apr 20, 2004 Posts: 1094 Re: [flyangel2] Controversial? Including complete posts when replying..agggh! - NEW [In reply to] Quote | Reply -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Quote -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- In Reply To -------------------------------------------------------------------------------- Is it just me or does anyone else find the current practise of copy and pasting the ENTIRE contents of the post being replied to in a response, a pain in the arse? Often many...many .... many paragraphs If the initial post was interesting.... we all read it If it wasn't .... including it again doesn't improve it any..... Just my 2p worth. -------------------------------------------------------------------------------- Bawhaha.......I know who does that BTW, it isn't necessary to copy the whole post. WOW WHAT A RIDE!! -------------------------------------------------------------------------------- You taking the piss? Tony _________________________________ If I'm the best result of 100Million wrigglers, Then thank fuck the others never made it ;-) Keith Jumps License In sport : 630 : D 23850 : 6 years Oct 19, 2005, 4:57 PM Post #4 of 12 (72 views) Copy Shortcut Registered: Aug 14, 2001 Posts: 2776 Re: [shropshire] Controversial? Including complete posts when replying..agggh! - NEW [In reply to] Quote | Reply -------------------------------------------------------------------------------- That's the way the system is set up when you click "quote." Keith Don't Fuck with me Keith - J. Mandeville flyangel2 Jumps License In sport : 3333 : D : 26 years Oct 19, 2005, 5:00 PM Post #5 of 12 (69 views) Copy Shortcut Registered: Oct 25, 2002 Posts: 9879 Re: [Keith] Controversial? Including complete posts when replying..agggh! - NEW [In reply to] Quote | Reply -------------------------------------------------------------------------------- Yes, but you can cut and copy the items from the post that you want to address. WOW WHAT A RIDE!! Keith Jumps License In sport : 630 : D 23850 : 6 years Oct 19, 2005, 5:46 PM Post #6 of 12 (49 views) Copy Shortcut Registered: Aug 14, 2001 Posts: 2776 Re: [flyangel2] Controversial? Including complete posts when replying..agggh! - NEW [In reply to] Quote | Reply -------------------------------------------------------------------------------- True, I'm just saying if you use use the "quote" function as it is, then everything is "cut and pasted" into your response. I rarely use it for that reason. Keith Don't Fuck with me Keith - J. Mandeville sinker Jumps License In sport : 38 : A : Oct 19, 2005, 6:12 PM Post #7 of 12 (39 views) Copy Shortcut Registered: Jan 3, 2003 Posts: 3001 Re: [shropshire] Controversial? Including complete posts when replying..agggh! - NEW [In reply to] Quote | Reply -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- In Reply To -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Quote -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- In Reply To -------------------------------------------------------------------------------- Is it just me or does anyone else find the current practise of copy and pasting the ENTIRE contents of the post being replied to in a response, a pain in the arse? Often many...many .... many paragraphs If the initial post was interesting.... we all read it If it wasn't .... including it again doesn't improve it any..... Just my 2p worth. -------------------------------------------------------------------------------- Bawhaha.......I know who does that BTW, it isn't necessary to copy the whole post. WOW WHAT A RIDE!! -------------------------------------------------------------------------------- You taking the piss? -------------------------------------------------------------------------------- That's the way the system is set up when you click "quote." Keith Don't Fuck with me Keith - J. Mandeville Yes, but you can cut and copy the items from the post that you want to address. WOW WHAT A RIDE!! True, I'm just saying if you use use the "quote" function as it is, then everything is "cut and pasted" into your response. I rarely use it for that reason. Keith Don't Fuck with me Keith - J. Mandeville -------------------------------------------------------------------------------- Quote -------------------------------------------------------------------------------- some people just like to be annoying Iguess.. "I don't need no one to tell me about Heaven I look at my children and I believe..." (This post was edited by sinker on Oct 19, 2005, 6:21 PM) Keith Jumps License In sport : 630 : D 23850 : 6 years Oct 19, 2005, 6:16 PM Post #8 of 12 (37 views) Copy Shortcut Registered: Aug 14, 2001 Posts: 2776 Re: [sinker] Controversial? Including complete posts when replying..agggh! - NEW [In reply to] Quote | Reply -------------------------------------------------------------------------------- Where's your icon? Did the novelty wear off already? Keith Don't Fuck with me Keith - J. Mandeville sinker Jumps License In sport : 38 : A : Oct 19, 2005, 6:22 PM Post #9 of 12 (33 views) Copy Shortcut Registered: Jan 3, 2003 Posts: 3001 Re: [Keith] Controversial? Including complete posts when replying..agggh! - NEW [In reply to] Quote | Reply -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- In Reply To -------------------------------------------------------------------------------- Where's your icon? Did the novelty wear off already? -------------------------------------------------------------------------------- there, changed it for ya! "I don't need no one to tell me about Heaven I look at my children and I believe..." quade Moderator Jumps License In sport : 2600 : D 22635 : 7 years Oct 19, 2005, 6:53 PM Post #10 of 12 (25 views) Copy Shortcut Registered: Dec 10, 1999 Posts: 12269 Re: [shropshire] Controversial? Including complete posts when replying..agggh! - NEW [In reply to] Quote | Reply -------------------------------------------------------------------------------- There are times when it makes sense, but 99% of the time it would be FAR better to just copy and paste the relevant parts. IF you're addressing more than a couple of parts, then just copy and paste those. IF you're reponding point by point to each and every line . . . you're probably wasting your time and efforts. -------------------------------------------------------------------------------- quade - futurecam.com skydyvr Jumps License In sport : 84 : A 43 : 2 years Oct 19, 2005, 7:02 PM Post #11 of 12 (19 views) Copy Shortcut Registered: Nov 11, 2002 Posts: 1772 Re: [shropshire] Controversial? Including complete posts when replying..agggh! - NEW [In reply to] Quote | Reply -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- In Reply To -------------------------------------------------------------------------------- Is it just me or does anyone else find the current practise of copy and pasting the ENTIRE contents of the post being replied to in a response, a pain in the arse? Often many...many .... many paragraphs -------------------------------------------------------------------------------- Quoting an entire lengthy post for some three word reply is an act of laziness, equitable to crapping in your own backyard -- it's the easy thing to do. In fact, I've noticed a real correlation between people who crap in their own backyard politically, and people who post long, useless quotes. Coincidence? I think not. ________ First, we shoot all the chicken de-beakers. flyangel2 Jumps License In sport : 3333 : D : 26 years Oct 19, 2005, 9:17 PM Post #12 of 12 (2 views) Copy Shortcut Registered: Oct 25, 2002 Posts: 9879 Re: [skydyvr] Controversial? Including complete posts when replying..agggh! - NEW [In reply to] Quote | Reply -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- In Reply To -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- In Reply To -------------------------------------------------------------------------------- Is it just me or does anyone else find the current practise of copy and pasting the ENTIRE contents of the post being replied to in a response, a pain in the arse? Often many...many .... many paragraphs -------------------------------------------------------------------------------- Quoting an entire lengthy post for some three word reply is an act of laziness, equitable to crapping in your own backyard -- it's the easy thing to do. In fact, I've noticed a real correlation between people who crap in their own backyard politically, and people who post long, useless quotes. Coincidence? I think not. -------------------------------------------------------------------------------- Well that counts me out, since most times my reply is longer then three lines. Let's see, what should I say now, just to take up some space. Oh I got it...............I'm out of here WOW WHAT A RIDE!! General Announcements Introductions and Greets Community The Bonfire Speakers Corner Women Only Skydivers with Disabilities Skydiving General Skydiving Discussions Safety and Training Gear and Rigging Instructors Incidents Wind Tunnels Events & Places to Jump Skydiving History & Trivia Skydiving Disciplines Swooping and Canopy Control Relative Work Freeflying Canopy Relative Work Wing Suit Flying Photography and Video Related Sports The BASE Zone International En Français Foro de Salto libre Stammtisch Äðîïçîíà.com Dropzone.com Security and Scam Alerts Suggestions and Feedback Error and Bug Reports Archive 2005-2006 USPA BOD Elections Search this forum this category all forums for All words Any words Whole Phrase (options) Help About Advertise Terms Privacy Contact Us © 1994-2005 Dropzone.com - All rights reserved "...And once you're gone, you can't come back When you're out of the blue and into the black." Neil Young
  16. Shouldn't it be tobacco that ought to be illegal. The one drug that has consistently shown to be the most beneficial to the humanrace is the one drug that has so blatantly villified by governments the world over. Marijuana could possiably be the link to curing cancer and a number of other ailments. CANNABIS AND TOBACCO SMOKE ARE NOT EQUALLY CARCINOGENIC (Source:Harm Reduction Journal) Regional News United Kingdom ------- Tobacco has dramatic negative consequences for those who smoke it. In addition to its high addiction potential [1], tobacco is causally associated with over 400,000 deaths yearly in the United States, and has a significant negative effect on health in general [2]. More specifically, over 140,000 lung-related deaths in 2001 were attributed to tobacco smoke [3]. Comparable consequences would naturally be expected from cannabis smoking since the burning of plant material in the form of cigarettes generates a large variety of compounds that possess numerous biological activities [4]. While cannabis smoke has been implicated in respiratory dysfunction, including the conversion of respiratory cells to what appears to be a pre-cancerous state [5], it has not been causally linked with tobacco related cancers [6] such as lung, colon or rectal cancers. Recently, Hashibe et al [7] carried out an epidemiological analysis of marijuana smoking and cancer. A connection between marijuana smoking and lung or colorectal cancer was not observed. These conclusions are reinforced by the recent work of Tashkin and coworkers [8] who were unable to demonstrate a cannabis smoke and lung cancer link, despite clearly demonstrating cannabis smoke-induced cellular damage. Furthermore, compounds found in cannabis have been shown to kill numerous cancer types including: lung cancer [9], breast and prostate [10], leukemia and lymphoma [11], glioma [12], skin cancer [13], and pheochromocytoma [14]. The effects of cannabinoids are complex and sometimes contradicting, often exhibiting biphasic responses. For example, in contrast to the tumor killing properties mentioned above, low doses of THC may stimulate the growth of lung cancer cells in vitro [15]. The genotoxic effects of partially oxidized hydrocarbons created by burning either cannabis or tobacco have been widely examined as the likely source of genetic changes that lead to the carcinogenic state [16]. As a result, the medical potential of cannabis has been obscured by the potential negative impact of using a smoked medicine [17]. Those who deny the validity of "medical marijuana," cite that marijuana smoke contains four fold more tars than does tobacco smoke [18]. Nevertheless, smoking is often the preferred route of intake by medical cannabis users because rapid action allows selftitration [19]. Are the biological consequences of smoking cannabis and tobacco similar? Smoke from tobacco and cannabis contains many of the same carcinogens and tumor promoters [20][21]. However, cannabis and tobacco have additional pharmacological activities, both receptor-dependent and independent, that result in different biological endpoints. Polycyclic aromatic hydrocarbons found in smoke are procarcinogens that are converted to carcinogens by the enzymatic activity of the cytochrome P4501A1 oxidase protein ( CYP1A1 gene product ). Benzo [a] pyrene is converted to its carcinogenic metabolite diol epoxide, which binds to specific hypermutable nucleotide sequences in the K-ras oncogene and p53 tumor suppressor [22]. Recent work by Roth et al. demonstrates that THC treatment of murine hepatoma cells caused a dose dependent increase in CYP1A1 gene transcription, while at the same time directly inhibiting the enzymatic activity of the gene product [23]. Thus, despite potentially higher levels of polycyclic aromatic hydrocarbons found in cannabis smoke compared to tobacco smoke ( dependent on what part of the plant is smoked ), the THC present in cannabis smoke should exert a protective effect against pro-carcinogens that require activation. In contrast, nicotine activates some CYP1A1 activities, thus potentially increasing the carcinogenic effects of tobacco smoke [24]. It is worth noting that cytochrome P4501A1 oxidase has numerous substrates including biologically active lipid metabolites such as arachidonic acid, and eicosinoids [25]. These molecules are components of metabolic pathways that are interwoven with the synthesis and degradation of endocannabinoids such as arachidonylethanolamine ( anandamide ) [26]. Hence, the inhibition of cytochrome P4501A1 oxidase by THC is likely to have multiple biological effects such as possibly enhancing cannabinoid activities by decreasing their catabolism. The need to better understand the biological consequences of tobacco compared to cannabis smoke has been underscored by recent studies that demonstrate a unique role for nicotine in the pathogenesis of lung cancer [27]. In order to appreciate potential biological differences between tobacco and cannabis smoke, the molecular basis of signal transduction must be considered with respect to the life and death of cells. Evolution has provided cells with biochemical feedback loops, checkpoints that monitor genetic integrity and the overall state of the cell. Under conditions of sufficient cellular damage, apoptotic cell death is induced [28]. While a variety of different biochemical states are consistent with a cell either living or dying, constant communication between a cell and its environment is critical for survival of the cell and ultimately the organism. Cells communicate with each other via specific cell surface receptors. When bound with their appropriate ligand, the receptors initiate signaling cascades that alter cellular biochemistry [29]. THC found in cannabis [30] and nicotine found in tobacco [31] both have specific receptors by which their corresponding ligands modulate cellular functions. Interestingly, both cannabinoid [32] and nicotine receptors [27] are coupled to the AKT ( PKB ) signaling pathway. Activation of either receptor type can induce an anti apoptotic state that prevents cell death. However, it is the context in which the AKT pathway is activated that determines whether an organism benefits or is harmed by this anti-apoptotic activity. Nicotine receptors are widely distributed and are found in the epithelial cells lining respiratory passages. Cannabinoid receptors are also widely distributed, but have not been reported in respiratory epithelial cells. The differential expression of receptors may account for the apparent difference in carcinogenic activity that results from smoking tobacco compared to cannabis. Both types of smoke contain a complex mixture of compounds, some of which are carcinogenic. They both contain hot gasses and irritating particulate matter ( tars ). However, the anti-apoptotic response that results from the stimulation of the nicotine receptors, under mutagenic conditions, creates a worstcase scenario. The very cells that have accumulated sufficient genetic damage to normally initiate the apoptotic cascade are prevented from going down this suicidal path [33] even though it would be best for the organism as a whole. In contrast, when the AKT pathway is activated in the brain after head injury [34] or stroke, [35] cannabinoids protect against cell death to the organism's benefit. Likewise, nicotine can also activate the AKT pathway in the brain in a beneficial manner. For example, activation of the nicotine receptors, as is also true of cannabinoid receptors [36], can prevent the brain cell death that results from exposure to beta amyloid protein [37] as occurs in Alzheimer's disease. The impact of receptor and downstream activation is complicated. Both nicotine and cannabinoids have been shown to effect angiogenesis in a receptor-mediated manner [13]. However, nicotine and tobacco have opposite effects on angiogenesis. Nicotine promotes neo-vacularization along with associated tumor growth, atheroma, upregulation of VEGF, and cell migration [38]. In contrast, cannabinoids promote tumor regression in rodents and inhibit pro-angiogenic factors [39]. In fact, clinical trials to treat human glioma with THC have resulted in decreased levels of VEGF [40]. The signal transduction pathway described above represents one means by which the carcinogenic affects of tobacco are amplified in a contrasting manner to what occurs with cannabis. The immunological effects resulting from smoking tobacco or cannabis are also distinctive and result in opposite end-points. Again, the carcinogenic potential of smoke is increased by tobacco, whereas it is uniquely reduced by the specific immune regulatory activity of cannabinoids in cannabis smoke. The introduction of hot gaseous material containing both carcinogens and particulate material into the respiratory passages produces pro-inflammatory immune responses [41]. The inflammatory state is a double-edged sword that can serve to protect or kill an organism. A functional characteristic of the pro-inflammatory state is the production of free radicals [42]. These reactive chemical species are essential armaments in the body's defense against various pathogens, in particular against intracellular parasites and bacteria. Free radicals are thought to be contributing etiological agents behind a number of pathological states [43] including cardiovascular and neuro-degenerative diseases [44], cancers, and aging in general [45]. Endocannabinoids are specific immunological homeostatic modulators when acting on "peripheral" CB2 receptors [30]. Both endo- and exo-cannabinoids push the immune system towards the relatively anti-inflammatory Th2 cytokine profile [46]. Thus, cannabinoids inhaled in cannabis smoke physiologically reduce the potential amplification of carcinogens in smoke that results from biologically produced free radicals. This response is not induced by tobacco smoke. In conclusion, while both tobacco and cannabis smoke have similar properties chemically, their pharmacological activities differ greatly. Components of cannabis smoke minimize some carcinogenic pathways whereas tobacco smoke enhances some. Both types of smoke contain carcinogens and particulate matter that promotes inflammatory immune responses that may enhance the carcinogenic effects of the smoke. However, cannabis typically down-regulates immunologically-generated free radical production by promoting a Th2 immune cytokine profile. Furthermore, THC inhibits the enzyme necessary to activate some of the carcinogens found in smoke. In contrast, tobacco smoke increases the likelihood of carcinogenesis by overcoming normal cellular checkpoint protective mechanisms through the activity of respiratory epithelial cell nicotine receptors. Cannabinoids receptors have not been reported in respiratory epithelial cells ( in skin they prevent cancer ), and hence the DNA damage checkpoint mechanism should remain intact after prolonged cannabis exposure. Furthermore, nicotine promotes tumor angiogenesis whereas cannabis inhibits it. It is possible that as the cannabis-consuming population ages, the long-term consequences of smoking cannabis may become more similar to what is observed with tobacco. However, current knowledge does not suggest that cannabis smoke will have a carcinogenic potential comparable to that resulting from exposure to tobacco smoke. It should be noted that with the development of vaporizers, that use the respiratory route for the delivery of carcinogen-free cannabis vapors, the carcinogenic potential of smoked cannabis has been largely eliminated [47][48]. REFERENCES 1. Khurana S, Batra V, Patkar AA, Leone FT: Twenty-first century tobacco use: it is not just a risk factor anymore. Respir Med. 2003, 97( 4 ):295-301. 2. Thun MJ, Henley SJ, Calle EE: Tobacco use and cancer: an epidemiologic perspective for geneticists. Oncogene. 2002, 21( 48 ):7307-7325. 3. Alavanja MC: Biologic damage resulting from exposure to tobacco smoke and from radon: implication for preventive interventions. Oncogene. 2002, 21( 48 ):7365-7375. 4. Novotny, M., Merli F, Weisler D, Fencl M, Saeed T: Fractionation and capillary gas chromatographic-mass spectrometric characterization of the neutral components in marijuana and tobacco smoke condensates. J Chromatogr. 1982, 238:141-150. 5. Tashkin DR, Baldwin GC, Sarafian T, Dubinett S, Roth MD: Respiratory and immunologic consequences of marijuana smoking. J Clin Pharmacol. 2002, 42( 11 Suppl ):71S-81S. 6. Sidney S, Beck JE, Tekawa IS, Quesenberry CP, Friedman GD: Marijuana use and mortality. Am J Public Health. 1997, 87:585-590. 7. Hashibe M, Straif K, Tashkin DP, Morgenstern H, Greenland S, Zhang ZF: Epidemiologic review of marijuana use and cancer risk. Alcohol. 2005, 35:265- 275. 8. Tashkin DP: Smoked marijuana as a cause of lung injury. Monaldi Arch Chest Dis. 2005, 63:93-100. 9. Munson AE, Harris LS, Friedman MA, Dewey WL, Carchman RA: Antineoplastic activity of cannabinoids. J Natl Cancer Inst. 1975, 55:597-602. 10. Sanchez C, de Ceballos ML, del Pulgar TG, Rueda D, Corbacho C, Velasco G, Galve-Roperh I, Huffman JW, Ramon y Cajal S, Guzman M: Inhibition of glioma growth in vivo by selective activation of the CB( 2 ) cannabinoid receptor. Cancer Res. 2001, 61:5784-5789. 11. McKallip RJ, Lombard C, Fisher M, Martin BR, Ryu S, Grant S, Nagarkatti PS, Nagarkatti M: Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease. Blood. 2002, 100:627-634. 12. Sanchez C, Galve-Roperh I, Canova C, Brachet P, Guzman M: Delta9- tetrahydrocannabinol induces apoptosis in C6 glioma cells. FEBS Lett. 1998, 436:6-10. 13. Casanova ML, Blazquez C, Martinez-Palacio J, Villanueva C, Fernandez-Acenero MJ, Huffman JW, Jorcano JL, Guzman M: Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. J Clin Invest. 2003, 111:43-50. 14. Sarker KP, Obara S, Nakata M, Kitajima I, Maruyama I: Anandamide induces apoptosis of PC-12 cells: involvement of superoxide and caspase-3. FEBS Lett. 2000, 472:39-44. 15. Hart S, Fischer OM, Ullrich A: Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme ( TACE/ADAM17 )-mediated transactivation of the epidermal growth factor receptor. Cancer Res. 2004, 64:1943-1950. 16. Godschalk R, Nair J, van Schooten FJ, Risch A, Drings P, Kayser K, Dienemann H, Bartsch H: Comparison of multiple DNA adduct types in tumor adjacent human lung tissue: effect of cigarette smoking. Carcinogenesis. 2002, 23:2081- 2086. 17. Watson SJ, Benson JAJ, Joy JE: Marijuana and medicine: assessing the science base: a summary of the 1999 Institute of Medicine report. Arch Gen Psychiatry. 2000, 57( 6 ):547-552. 18. Wu TC, Tashkin DP, Djahed B, Rose JE: Pulmonary hazards of smoking marijuana as compared with tobacco. N Engl J Med. 1988, 318:347-351. 19. Grotenhermen F: Pharmacokinetics and pharmacodynamics of cannabinoids. Clin Pharmacokinet. 2003, 42( 4 ):327-360. 20. Nebert DW, Gonzalez FJ: P450 genes: structure, evolution, and regulation. Annu Rev Biochem. 1987, 56:945-993. 21. Hecht SS, Carmella SG, Murphy SE, Foiles PG, Chung FL: Carcinogen biomarkers related to smoking and upper aerodigestive tract cancer. J Cell Biochem Suppl. 1993, 17F:27-35. 22. Tretyakova N, Matter B, Jones R, Shallop A: Formation of benzo[a]pyrene diol epoxide-DNA adducts at specific guanines within K-ras and p53 gene sequences: stable isotope-labeling mass spectrometry approach. Biochemistry. 2002, 41:9535-9544. 23. Roth MD, Marques-Magallanes JA, Yuan M, Sun W, Tashkin DP, Hankinson O: Induction and regulation of the carcinogen-metabolizing enzyme CYP1A1 by marijuana smoke and delta ( 9 )-tetrahydrocannabinol. Am J Respir Cell Mol Biol. 2001, 24:339-344. 24. Price RJ, Renwick AB, Walters DG, Young PJ, Lake BG: Metabolism of nicotine and induction of CYP1A forms in precision-cut rat liver and lung slices. Toxicol In Vitro. 2004, 18:179-185. 25. Nebert DW, Russell DW: Clinical importance of the cytochromes P450. Lancet. 2002, 360( 9340 ):1155-1162. 26. Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, Gibson D, Mandelbaum A, Etinger A, Mechoulam R: Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science. 1992, 258:1946- 1949. 27. West KA, Brognard J, Clark AS, Linnoila IR, Yang X, Swain SM, Harris C, Belinsky S, Dennis PA: Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. J Clin Invest. 2003, 111:81-90. 28. Woo RA, Poon RY: Cyclin-Dependent Kinases and S Phase Control in Mammalian Cells. Cell Cycle. 2003, 2:316-324. 29. Bockaert J, Pin JP: Molecular tinkering of G protein-coupled receptors: an evolutionary success. EMBO J. 1999, 18( 7 ):1723-1729. 29. Bockaert J, Pin JP: Molecular tinkering of G protein-coupled receptors: an evolutionary success. EMBO J. 1999, 18( 7 ):1723-1729. 30. Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, Devane WA, Felder CC, Herkenham M, Mackie K, Martin BR, Mechoulam R, Pertwee RG: International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol Rev. 2002, 54( 2 ):161-202. 31. Itier V, Bertrand D: Neuronal nicotinic receptors: from protein structure to function. FEBS Lett. 2001, 504( 3 ):118-125. 32. Gomez del Pulgar T, Velasco G, Guzman M: The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt. Biochem J. 2000, 347:369- 373. 33. Minna JD: Nicotine exposure and bronchial epithelial cell nicotinic acetylcholine receptor expression in the pathogenesis of lung cancer. J Clin Invest. 2003, 111( 1 ):31-33. 34. Panikashvili D, Simeonidou C, Ben-Shabat S, Hanus L, Breuer A, Mechoulam R, Shohami E: An endogenous cannabinoid ( 2-AG ) is neuroprotective after brain injury. Nature. 2001, 413:527-531. 35. Leker RR, Shohami E, Abramsky O, Ovadia H: Dexanabinol; a novel neuroprotective drug in experimental focal cerebral ischemia. J Neurol Sci. 1999, 162:114-119. 36. Iuvone T, Esposito G, Esposito R, Santamaria R, Di Rosa M, Izzo AA: Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells. J Neurochem. 2004, 89:134-141. 37. Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Shibasaki H, Kume T, Akaike A: alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity. J Biol Chem. 2001, 276:13541-13546. 38. Heeschen C, Jang JJ, Weis M, Pathak A, Kaji S, Hu RS, Tsao PS, Johnson FL, Cooke JP: Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis. Nat Med. 2001, 7:833-839. 39. Galve-Roperh I, Sanchez C, Cortes ML, del Pulgar TG, Izquierdo M, Guzman M: Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. Nat Med. 2000, 6:313-319. 40. Blazquez C, Gonzalez-Feria L, Alvarez L, Haro A, Casanova ML, Guzman M: Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas. Cancer Res. 2004, 64:5617-5623. 41. Sarafian TA, Magallanes JA, Shau H, Tashkin D, Roth MD: Oxidative stress produced by marijuana smoke. An adverse effect enhanced by cannabinoids. Am J Respir Cell Mol Biol. 1999, 20:1286-1293. 42. Chung HY, Kim HJ, Kim JW, Yu BP: The inflammation hypothesis of aging: molecular modulation by calorie restriction. Ann N Y Acad Sci. 2001, 928:327- 335 43. Raha S, Robinson BH: Mitochondria, oxygen free radicals, and apoptosis. Am J Med Genet. 2001, 106:62-70. 44. Halliwell B: Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment. Drugs Aging. 2001, 18:685-716. 45. Drew B, Leeuwenburgh C: Aging and the role of reactive nitrogen species. Ann N Y Acad Sci. 2002, 959:66-81. 46. Yuan M, Kiertscher SM, Cheng Q, Zoumalan R, Tashkin DP, Roth MD: Delta 9- Tetrahydrocannabinol regulates Th1/Th2 cytokine balance in activated human T cells. J Neuroimmunol. 2002, 133:124-131. 47. Mirken B. Vaporizers for medical marijuana. Aids Treat News No 327 1999; Sect. 1, 5. 48. Gieringer D, St. Laqurent J, Goodrich S. Cannabis Vaporizer Combines Efficient Delivery of THC with Effective Suppression of Pyrolytic Compounds. In: Journal of Cannabis Therapeutics. Russo, ed. 4. 2004:7-27. "...And once you're gone, you can't come back When you're out of the blue and into the black." Neil Young
  17. Most non-Americans I know would disagree. About half the Americans I know would also disagree. *** Americas image has been on a decline since the Korean war and got on a face track during the Vietnam war. I recall several protestes against our battle group back in the early 80's in several ports. What the world seems to fear is that the USA will not stop untill all governments bow down to a New World Order set forth by the Federal Governmet. We are not seen as a shining beacon but more as a war mongering rogue. The world understood the attack on the taliban and supported the attempt. Yet at the same time they watch the military forces pour into Iraq with no cause to do so when the threat was elsewhere. Not only Afghanastan but Iran and, the most vocal, North Korea. The world sees what is appearant. The USA will go after an easier target and hope that the greater danger does not strike again. This is how I see it and from what I gather so does a great number of others. "...And once you're gone, you can't come back When you're out of the blue and into the black." Neil Young
  18. Riding a fat chick is like riding a Jap bike. Feels alright... untill your Bros find out. "...And once you're gone, you can't come back When you're out of the blue and into the black." Neil Young
  19. Someone should inform the AFA that Thomas Jefferson was an athiest and that the rest were not that religous themselves. What they did believe, however, is that everyone has the right to believe as they wish and say what they want, as long as they are not harming anyone, without persecution. It is the ACLU whom are protecting the rights of such groups as the AFA. A bit ironic to say the least as the ACLU is one of the groups they oppose the most. "...And once you're gone, you can't come back When you're out of the blue and into the black." Neil Young
  20. You're fucking yourself if you take a car to a mechanic for anything. Buy a manual, preferably a Chilton Manual, read it and do the work yourself and save your money for skydiving. GODDAMN IT! BE A MAN! You should be able to build a 350 chevy with your eyes closed. Didn't you learn anything in your teenage years or were you to busy learning crap that you have never used. Come on, which one is it. Anyways, buy yourself the book and a Craftsman mechanic tool set and an assortment of testing devices. As far as the antifreeze goes, that should be done every fall. Antifreeze is cheap and you can change it yourself and dispose of the old at any parts shop. On the brake fluid, check what the car manufactuer suggest and follow that. Unless the brakes felt differant or the fluid was turning dark, then there was no reason for a "brake fluid flush" (sounds like a gimmick to snare those with no car knowledge). "...And once you're gone, you can't come back When you're out of the blue and into the black." Neil Young
  21. ***Yet when a professional athlete attacks someone during a game/meet/etc, they only get fined or a penalty - but assault is assault, and the cops should go onto the court/field/rink/etc and arrest them on the spot too. Do you feel the same way about them? To the original statement - No, the law should weigh equally whatever career you choose. In this case, it's a clear case of assault that would apply if they were cops or if they were hot dog vendors. That the other cops didn't arrest the lawbreaking one(s) of their own is where a specific law and punishment set needs to be defined relating to the duty to arrest law breakers of all kinds (on duty? can't ignore a crime). very true - but punishment must be relative to the crime committed and the potential of it being a repeat. Not relative to the outrage or surprise of the observers - else punishment becomes some weird sort of popularity contest without parity. I believe that with professional athletes go, it is how much money you have. No real justice is served. Some of the highest paid pros have walked on some very serious offenses. It has been that way since they have reached superstar status. It makes the lot of them look bad. The same goes with police. Due to their status in society a lot of people will turn their heads when the police step out of line. A lot of police officer too will look the other way. Whether or not the man they were arresting was in fact resisting (a charge that is way too ofton used unjustly) or not, does not warrant a beating by the police. As their job is to uphold the law and be an example then they should be held to a higher level than the general population. My nephew is a police officer in the Kansas City area, I would feel a lot of shame if he were to act in the way some cops do. If the police are going to arrest and then punish why the hell do we need a court system? "...And once you're gone, you can't come back When you're out of the blue and into the black." Neil Young
  22. I cannot forgive anyone who abuse the power given to them to uphold the law. When police act in such a mannner that the law does not apply to them then they are the most guilty and the law should weigh heavier upon them. It is not their job to dole out punishment. Their job is only to apperhend the offender and nothing else. Understandable the stress but if an officer cannot act in a proffessional capacity when confronted with stress that officer needs to remove his/her badge. "...And once you're gone, you can't come back When you're out of the blue and into the black." Neil Young
  23. The F-102 was in fact deemed unsuitable for any combat and by 1969 they have all left Vietnam. The F-102 Delta Dagger was an active part of US Air Defense Command from 1956 to 1974. Most of the F-102s and F-106s in service were part of ANG units and over 1000 F-102s were made. Hardly obsolete. The F-106 served into the 1990s. Consider the B-52, in service since 1955, it will probably outlast the B-1 and B-2. -------------------------------------------------------------------------------- In Reply To -------------------------------------------------------------------------------- ( in Vietnam the Guard did NOT go... period.. so it was a good place for the rich boys to run off to while maintaining the appearance of serving.. and Bushie did not even bother to show up.. and had some mediocre performance reports even before that.) Most of the rest of the clowns there in the executive branch did not even bother to do that. -------------------------------------------------------------------------------- While active duty units were in Vietnam, it was ANG units that took up the slack to be the readiness to intercept a Soviet attack. You know that the reports of his not showing up were bogus right? Or, did you too believe Dan Rather? A few Pacific-based squadrons got F-102s, the first being the 16th FIS based at Naha AFB on Okinawa which re-equipped in March of 1959. It was in the Pacific theatre that the F-102 was to achieve its only taste of combat. Aircraft from the 590th Fighter Interceptor Squadron were transferred to Tan Son Nhut AFB near Saigon in South Vietnam in March of 1962 to provide air defense against the unlikely event that North Vietnamese aircraft would attack the South. F-102As continued to be based there and in Thailand throughout much of the Vietnam war. F-102As stood alert at Bien Hoa and Da Nang in Sout Vietnam and at Udorn and Don Muang in Thailand. The F-102A was finally withdrawn from Southeast Asia in December of 1969. The F-102A established an excellent safety record in Vietnam. In almost ten years of flying air defense and a few combat air patrols for SAC B-52s, only 15 F-102As were lost. Although a few missions were flown over North Vietnam, the Southeast Asia-stationed F-102As are not thought to have actually engaged in air-to-air combat. However, one of my references has an F-102A of the 509th FIS being lost to an air-to-air missile fired by a MiG-21 while flying a CAP over Route Package IV on February 3, 1968. Two F-102As were lost to AAA/small arms fire and four were destroyed on the ground by the Viet Cong and eight were lost in operational accidents. Strange as it may seem, the F-102A actually did fly some close-support missions over the South, even though the aircraft was totally unsuited for this role. These operations started in 1965 at Tan Son Nhut using the 405 FW alert detachment. Operating under the code-name "Project Stovepipe", they used their heat sinking Falcon missiles to lock onto heat sources over the Ho Chi Minh trail at night, often Viet Cong campfires. This was more of a harassment tactic than it was serious assault. They would even fire their radar-guided missiles if their radars managed to lock onto something. The pilots were never sure if they actually hit anything, but they would sometimes observe secondary explosions. The F-102s soon switched to a day role, firing the 12 unguided FFAR rockets from the missile bays, using the optical sight. 618 day sorties were flown, the last one being flown at the end of 1965. One F-102A was downed by ground fire during one of these rocket attacks. There were some later missions flown, especially in Mayday emergencies when the 102's were the fastest response available in the South (2 1/2 minutes over the fence, far faster than the F-4). During the early 1960s, the F-102A was gradually replaced in the ADC by the McDonnell F-101B Voodoo and the Convair F-106 Delta Dart. By mid-1961, the number of F-102As in service with the ADC was down to 221. However, by the end of 1969, with the exception of a squadron maintained in Iceland, all ADC F-102As had been transferred to the Air National Guard. The F-102As stationed in the Pacific had been withdrawn in December of 1969. The only F-102As still in service with the USAF at the beginning of 1970 were all stationed overseas. At that time, the USAF still retained a few F-102A squadrons in Germany and the Netherlands. In the early 1970s, European-based F-102As were replaced by F-4 Phantoms. By the end of June 1973, the number of active F-102As had been reduced to ten. The last ADC unit to operate the F-102A, the 57th FIS based at Keflavik in Iceland finally traded in its F-102As for McDonnell F-4C Phantoms in mid-1973. As they left USAF service, most F-102As were transferred to the Air National Guard. First to receive the F-102A was the 182nd FIS of the Texas ANG, receiving the plane in mid-1960. By 1966, ANG inventories amounted to 339 F-102As. Twenty-three ANG units ultimately got F-102As, including ANG squadrons of Louisiana, Florida, Texas, North Dakota, Hawaii, Pennsylvania, New York, Washington, Connecticut, Oregion, Maine Vermont, Tennessee, Arizona, South Carolina, South Dakota, Wisconsin, Minnesota, Montana, Idaho, and California. A 1967 proposal to modify F-102As into RF-102As as the standard ANG reconnaissance aircraft was deemed infeasible and was not proceeded with. The F-102A was not equipped at the factory for midair refuelling. However, there were some examples of the F-102A that were fitted in the field with probe and drogue inflight-refuelling probes mounted immediately aft of the cockpit on the right-hand side of the fuselage. These were fitted for the purpose of ferrying aircraft from the US to Southeast Asia. The probes were removed upon arrival. Some ANG F-102As were also fitted with these midair refuelling probes. In the late 1960s, Convair proposed a close air support version of the F-102 equipped with an internally-mounted cannon. The USAF was not particularly interested and this idea got no further than the preliminary planning stage. Large-scale retirement of the F-102A from the ANG began in late 1969 and continued throughout the 1970s. The last F-102A finally left ANG service in October of 1976, when the 199th FIS of the Hawaii ANG traded in their Delta Daggers for F-4C Phantoms. Most of the retired F-102As ended up in the boneyards at the Davis-Monthan AFB storage facility. Many were subsequently converted into remote-controlled drone aircraft. "...And once you're gone, you can't come back When you're out of the blue and into the black." Neil Young
  24. Have never taken ambien. I am still working on a stash of Quaalude Rorer 714's that I squirreled away back in the 70's.
  25. It is great that the People Easily Trained by Animals show that children can have just as much fun killing fish with father as they can killing bunnies with mom. YUMMMMMMMMMM surf and turf. "...And once you're gone, you can't come back When you're out of the blue and into the black." Neil Young