ChromeBoy

There's people there...I will be back shortly...The House is a Rockin'

Freefly with Lummy...chase the lummy...CHASE the Lummy. Quotin' Lummy.

Boobies work every time!

Congrats Emmie. I will be there soon so we can jump once you get off probation! You got your new rig all muddy? Oh well, at least you passed! I am officially moving to Westborough the weekend of the 26th of April. I will be there soon! As for the payback to the JM...I will leave that for someone else.

But nobody's there. Empty bar. Should we lock the doors or rock the joint?

That ultimate fantasy of the couch potato may become a reality some day, according to researchers who have found the chemical pathways that muscle cells use to build strength and endurance. With this basic knowledge in hand, it now may be possible to develop a pill that pumps up muscle cells without all that exercise, said Dr. R. Sanders Williams, dean of the Duke University of School of Medicine and senior author of a study appearing Friday in the journal Science. Does this mean sedentary people could build muscle by taking pills? "That may be one of the possibilities," said Williams, but the main target of the research is to promote the health of people with heart disease or other conditions that keep them from doing enough exercise. "This could lead to drugs that will let people get the health benefits of regular exercise, even if they cannot exercise," said Williams. This could help patients with heart or lung disease, or lower the risk of Type II diabetes, for instance. "It is possible it could become a drug of abuse because it would enhance the performance of athletes," he said. In the study, Williams and colleagues at the University of Texas Southwestern Medical Center in Dallas created a group of mice with genes that made a surplus of a protein called calmodulin-dependent protein kinase, or CaMK. When this protein is activated, it and another protein, calcineurin, trigger the physical changes that muscle cells undergo after intense exercise. Williams said mice with a high level of CaMK developed more mitochondria in muscle cells and saw an increase of a type of cell called the "slow twitch" muscle. These are muscle cells that power sustained activity, such as that required by marathon runners. For "fast twitch" muscles, which provide a burst of strength for a short period of time, there was an increase in the number of mitochondria. The researchers found that mice with high levels of CaMK developed the same healthy muscle cells as mice that did exercise. "The effect increases more of the slow twitch muscles, but it also increases the number of mitochondia in the fast twitch muscle cells," he said. "That is very similar to what happens in very intense training." Mitochondria are structures inside a cell that provide energy by metabolizing oxygen and nutrition. Cells with many mitochondria can produce more work over a longer time. Physical training increases the number of mitochondria in muscle cells. Williams said a drug that would trigger the CaMK muscle signaling pathway has not been found, but now that there is a specific target it should made the development easier. "Pharmaceutical companies are very good at that," he said. Dr. Keshav Singh of Johns Hopkins University School of Medicine said the paper by Williams and his group is an "important advancement in understanding the mechanism that creates more mitochondria in muscles." "Since levels of mitochondrial proteins decrease with normal aging, this study may also help develop therapies to increase the physical endurance in the aged," said Singh, who is a mitochondria researcher at Hopkins. Copyright 2002 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.

Where were you Chuck?

Ever wonder about those people who say they are giving more than100%? We have all been to those meetings where someone wants over 100%. How about achieving 103%? Here's a little math that might prove helpful. What makes life 100%? If A B C D E F G H I J K L M N O P Q R S T U V W X Y Z is represented as: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 Then, H A R D W O R K 8 1 18 4 23 15 18 11 = 98% K N O W L E D G E 11 14 15 23 12 5 4 7 5 = 96% A T T I T U D E 1 20 20 9 20 21 4 5 = 100% And, B U L L S H I T 2 21 12 12 19 8 9 20 = 103% So, it stands to reason that hardwork and knowledge will get you close, attitude will get you there, but bullshit will put you over the top. And, look how far... A S S K I S S I N G 1 19 19 11 9 19 19 9 14 7 = 118% will take you

I will admit it is one of the funniest things I have seen in awhile. Even before Daves pic with Denogopher and the sheep!

PLF it is now time for your ass and frontal shots. No socks though. I can guarantee Dave will leave it alone as well.

I am not a stalker or am I in love with Dave or TequilaGirl. Just wanted to say hi to Dave!

Are you just gonna keep postin'? ...j/k...

I don't know any dz's but out in the West Texas side of El Paso I fell in love with a Mexican girl.

Hi Dave!

Hi Dave!

Yeppers... http://www.dropzone.com/dropzone/North_America/Canada/index.html

Try saying that four times in a row. {smile]

Dave...please don't. I will have to go out and purchase all the picture gizmos you have and emberass you!

Throw me a freakin' bone here. I'm the boss...I need the info. Congrats on your truck N2. Good luck with the final.

Bwwwaaahahhahahahahah! More dave....More...

Who's More Annoying Teletubbies Blues Clues Celine Dion Mariah Carey

I am sure they are all outraged with frustration.

Yes I am dissappointed.... I like big butts and I can not lie You other brothers can't deny That when a girl walks in with an itty bitty waist And a round thing in your face You get sprung Wanna pull up tough Cuz you notice that butt was stuffed Deep in the jeans she's wearing I'm hooked and I can't stop staring Oh, baby I wanna get with ya And take your picture My homeboys tried to warn me But that butt you got Make Me so horney Ooh, rump of smooth skin You say you wanna get in my benz Well use me use me cuz you aint that average groupy I've seen them dancin' The hell with romancin' She's Sweat,Wet, got it goin like a turbo vette I'm tired of magazines Saying flat butts are the thing

Whenever I was growing up I used to listen to Casey Kasems Top 40. Anyone else?

No photo....