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Spinal cord injury recovery through Polyethylene glycol administration in animal models

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Spinal cord injury can be divided into two stages. First is the mechanical injury, then comes the death of the neurons which causes surrounding neurons to die as well. It is this cascade reaction that causes a lot of the damage. Polyethylene glycol can protect the injured neurons (the white matter/axon) and restore function, thus stopping the cascade reaction in its tracks. Apparently this holds true for brain injury as well.

What it is:
http://www.mindfully.org/Plastic/Polymers/Polyethylene-Glycols-PEGs.htm

Some articles
http://www.fasebj.org/content/14/1/27.abstract
http://onlinelibrary.wiley.com/doi/10.1046/j.1471-4159.2002.01160.x/full
http://www.liebertonline.com/doi/abs/10.1089/neu.2005.22.1092
http://www.vet.purdue.edu/cpr/riyi/papers/64-Neuroprotection%20from%20secondary%20injury.pdf
http://www.apparelyzed.com/forums/topic/13350-findings-show-nanomedicine-promising-for-treating-spinal-cord-injuries/

Potential problems (toxicology)
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T4P-4754BM8-W2&_user=10&_coverDate=01/01/1989&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor&view=c&_searchStrId=1530255620&_rerunOrigin=scholar.google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=06027ae15b5591bc3528b42d6a2961b1&searchtype=a
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T4P-4754BM8-W2&_user=10&_coverDate=01/01/1989&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=dc17a0e25fc847b5344255fa2184f1d5&searchtype=a
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T6P-3YKM374-3R&_user=10&_coverDate=02/28/1995&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=4eceeab33d2b3febdb89dc2bd26f91e0&searchtype=a

better now?

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Coul dyou please edit your post so that it all fits instead of being a mile long?

That would be great

Thanks.:)

I'm not usually into the whole 3-way thing, but you got me a little excited with that. - Skymama
BTR #1 / OTB^5 Official #2 / Hellfish #408 / VSCR #108/Tortuga/Orfun

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Spinal cord injury can be divided into two stages of injury. First is the mechanical injury, then comes the death of the neurons which cause their surrounding neurons to die as well. It is this cascade reaction that causes the most damage. Polyethylene glycol can protect the damaged neuron (white matter) and restore function almost immediately, thus stopping the cascade reaction in its tracks. Apparently this holds true for brain injury as well.

What it is:
http://www.mindfully.org/Plastic/Polymers/Polyethylene-Glycols-PEGs.htm

Some articles
http://www.fasebj.org/content/14/1/27.abstract
http://onlinelibrary.wiley.com/doi/10.1046/j.1471-4159.2002.01160.x/full
http://www.liebertonline.com/doi/abs/10.1089/neu.2005.22.1092
http://www.vet.purdue.edu/cpr/riyi/papers/64-Neuroprotection%20from%20secondary%20injury.pdf
http://www.apparelyzed.com/forums/topic/13350-findings-show-nanomedicine-promising-for-treating-spinal-cord-injuries/[url]

Potential problems (toxicology)
[url]http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T4P-4754BM8-W2&_user=10&_coverDate=01/01/1989&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor&view=c&_searchStrId=1530255620&_rerunOrigin=scholar.google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=06027ae15b5591bc3528b42d6a2961b1&searchtype=a

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T4P-4754BM8-W2&_user=10&_coverDate=01/01/1989&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=dc17a0e25fc847b5344255fa2184f1d5&searchtype=a
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T6P-3YKM374-3R&_user=10&_coverDate=02/28/1995&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=4eceeab33d2b3febdb89dc2bd26f91e0&searchtype=a


TPM Sister#130ONTIG#1
I love vodka.I love vodka cause it rhymes with Tuaca~LisaH
You having a clean thought is like billyvance having a clean post.iluvtofly

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Coul dyou please edit your post so that it all fits instead of being a mile long?

That would be great

Thanks.:)



I fixed it for him.....;)
TPM Sister#130ONTIG#1
I love vodka.I love vodka cause it rhymes with Tuaca~LisaH
You having a clean thought is like billyvance having a clean post.iluvtofly

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Coul dyou please edit your post so that it all fits instead of being a mile long?

That would be great

Thanks.:)



I fixed it for him.....;)


So all he has to do is . . . what?

CUZ IT STILL AIN'T FIXED!:ph34r:
I'm not usually into the whole 3-way thing, but you got me a little excited with that. - Skymama
BTR #1 / OTB^5 Official #2 / Hellfish #408 / VSCR #108/Tortuga/Orfun

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Coul dyou please edit your post so that it all fits instead of being a mile long?

That would be great

Thanks.:)



I fixed it for him.....;)


So all he has to do is . . . what?

CUZ IT STILL AIN'T FIXED!:ph34r:



I am not a miracle worker just a clicky fixer...:P
TPM Sister#130ONTIG#1
I love vodka.I love vodka cause it rhymes with Tuaca~LisaH
You having a clean thought is like billyvance having a clean post.iluvtofly

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Anti-Freeze...YUM!



And all these years they were giving us grief about leaving it out where animals could find it.[:/]
See? We just just thinking about their health and well-being.B|
"There are only three things of value: younger women, faster airplanes, and bigger crocodiles" - Arthur Jones.

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Coul dyou please edit your post so that it all fits instead of being a mile long?
That would be great
Thanks.:)



Fixed.

(Isn't that just annoying as hell?)


ALMOST as bad as spelling errors.:D:D:)
I'm not usually into the whole 3-way thing, but you got me a little excited with that. - Skymama
BTR #1 / OTB^5 Official #2 / Hellfish #408 / VSCR #108/Tortuga/Orfun

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